Novel Biological Carbon Fixation Pathway to Increase Plant Yield
Perlumi Chemicals will develop a novel biological carbon fixation pathway with a more efficient carboxylase to better utilize CO2. Rubisco, the carbon-fixing enzyme central to the carbon fixation cycle in plants, is rather inefficient, limiting how much CO2 a plant can convert into sugars per unit time. The Perlumi team will improve pathway enzymes using metabolic modeling and directed evolution, and implement the novel pathway in living systems. Perlumi’s modeling shows the theoretical maximum speed increase is three times as fast as the Calvin-Benson cycle, the pathway for carbon assimilation in plants. In addition, the team has demonstrated a significant portion of the pathway in vitro using a purified enzyme assay as a proof of concept. The final project goal is a plant with a 50% increase in yield.
The novel biological carbon fixation pathway will yield plants with higher yields and reduced energy requirements for cultivation.